Download e-book for iPad: Advances in Molecular Toxicology, Vol. 2 by James C. Fishbein

By James C. Fishbein

ISBN-10: 0444530983

ISBN-13: 9780444530981

Advances in Molecular Toxicology positive aspects the most recent advances in the entire subspecialties of the vast region of molecular toxicology. Toxicology is the research of toxins and this sequence info the research of the molecular foundation through which an enormous array of brokers encountered within the human surroundings and produced through the human physique itself appear themselves as pollution. no longer strictly constrained to documenting those examples the sequence can also be occupied with the complicated net of chemical and organic occasions that supply upward push to toxin-induced signs and disorder. the recent applied sciences which are being harnessed to research and comprehend those occasions may also be reviewed by means of major staff within the box. Advances in Molecular Toxicology will record growth in all points of those swiftly evolving molecular elements of toxicology with a view towards targeted elucidation of either growth at the molecular point and on advances in technological techniques hired * innovative experiences by way of prime employees within the self-discipline. * intensive dissection of molecular features of curiosity to a vast variety of scientists, physisicans and any pupil within the allied disciplines. * cutting edge functions of technological concepts within the chemistry, biochemistry and molecular drugs.

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Additional resources for Advances in Molecular Toxicology, Vol. 2

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1. Bioactivation of troglitazone and other thiazolidinedione drugs The mechanisms of troglitazone-induced hepatotoxicity are not fully understood and seem to be multifactorial [18], one of the potential factors being the formation of reactive metabolites after enzyme-mediated bioactivation. Clinical and postmarketing surveillance indicated that troglitazone-induced hepatotoxicity was not a characteristic of TZD drugs in general although isolated case reports of hepatotoxic events for rosiglitazone and pioglitazone exist [29,30].

R. Patierno, DNA polymerase arrest by adducted trivalent chromium, Mol. Carcinog. 9 (1994) 122–133. [104] H. Arakawa, R. Ahmad, M. A. Tajmir-Riahi, A comparative study of calf thymus DNA binding to Cr(III) and Cr(VI) ions. Evidence for the guanine N-7-chromium-phosphate chelate formation, J. Biol. Chem. 275 (2000) 10150–10153. 24 James J. Covino and Kent D. E. G. J. Burrows, Spermine participates in oxidative damage of guanosine and 8-oxoguanosine leading to deoxyribosylurea formation, J. Am. Chem.

The major route of hepatic nefazodone clearance is metabolic transformation by cytochrome P450 3A4 [43–45]. Nefazodone metabolism leads to numerous polar biotransformation products that recently have been studied in a novel mass spectrometric approach employing high resolution accurate mass 39 Drug-Induced Hepatotoxicity spectrometry [46]. Besides primary oxidation reactions, nefazodone also undergoes N-dealkylation and gives rise to chlorophenyl-piperazine (m-CPP; Figure 10A). Regarding potential bioactivation processes leading to electrophilic metabolites capable of covalently modifying hepatic proteins, those primary and secondary phase I metabolites related to the aromatic hydroxylation occurring in para-position to the piperazine nitrogen are of particular interest.

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Advances in Molecular Toxicology, Vol. 2 by James C. Fishbein

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