By J.K. Aronson (Eds.)
The unwanted effects of gear Annual is designed to supply a serious and up to date account of latest details relating to opposed drug reactions and interactions from the clinician's perspective. less than the supervision of the sequence editors, a world workforce of specialist authors have accumulated jointly the most recent details on adversarial drug results from the foreign literature. as well as describing new stories of inauspicious drug results, the authors have subjected these reviews to severe research, environment them into context when it comes to scientific relevance and significance, and cross-referring to prior studies the place worthy. New opposed results are said and evaluated and formerly mentioned antagonistic results are re-evaluated within the gentle of the latest details. a unique function is the stories, during which chosen antagonistic results are mentioned extensive. using the booklet is greater by way of separate indexes, permitting the reader to go into the textual content through drug identify, hostile impact identify, or drug interplay. the present Annual is the 1st replace of the normal encyclopaedic paintings during this box, http://www.elsevier.nl/locate/isbn/0444500936Meyler's negative effects of substances, Fourteenth version, which used to be released in December 2000.
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Extra resources for A world-wide survey of new data and trends in adverse drug reactions
This latter case seems to raise the relevance of dosage in the production of the valvular pathology. Mitral and tricuspid insufficiency developed in a 36-year-old woman who had taken f e n phen for 24 months (43A). Transmission electron microscopy o f the mitral and tricuspid valves showed many areas that appeared to contain intracellular, virus-like particles clustered in the cytoplasm, with a mean diameter of 32 nanometers. Whether this finding was incidental or related to the underlying pathology was uncertain.
Quinidine had no effect on venlafaxine clearance in subjects who were poor metabolizers before treatment. The authors suggested that poor metabolizers may be at particular risk of venlafaxine toxicity, as could subjects who take inhibitors of CYP2D6. 5 mg/day was added to fluoxetine 20 mg/day (56c). Venlafaxine does not have direct anticholinergic effects, but could cause them indirectly as a result of its ability to increase noradrenergic neurotransmission. This effect would be expected only at much higher doses of venlafaxine than those used here, which led the author to suggest that in the presence of CYP2D6 inhibition by fluoxetine, venlafaxine concentrations could have been substantially higher than expected.
6. Nagorka AR, Bergson PS. Infant methamphetamine toxicity posing as scorpion envenomation. Pediatr Emerg Care 1998; 14: 350-1. 7. Kolecki P. Inadvertent methamphetamine poisoning in pediatric patients. Pediatr Emerg Care 1998; 14: 385-7. Central nervous system stimulants, drugs that suppress appetite 8. Suchard JR, Currry SC, Nagorka AR, Bergeson PS. Methamphetamine toxicity. Pediatr Emerg Care 1999; 15: 306. 9. Nagorka AR, Bergeson PS. Methamphetamine toxicity. Pediatr Emerg Care 1999; 15: 306.
A world-wide survey of new data and trends in adverse drug reactions by J.K. Aronson (Eds.)